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Zymutest HIA (HIT) Assay


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Correlation with anti-HPF4 antibodies (anti-lgG)

Effects of platelet lysate addition

Incidence of the Various Heparin Dependent Antibody Isotypes

Detection of heparin depandent antibodies

HIT Slides-Chicago-05-2007



The Hyphen BioMed HIA (HIT) ELISA kits are standardized and optimized enzyme immuno-assay designed for measuring global heparin-dependent antibodies of the IgG or IgM, IgA isotype, or all three in human plasma or serum, or in any biological fluid where these antibodies must be measured.

The Enzyme Immuno Assays proposed are fully optimized, easy to perform, and provide reliable measurements with high reproducibility.

This optimized assay is designed with a protein-heparin complex, immobilized, stabilized and saturated, which allows total accessibility of heparin for the reaction. This reliable method then provides high reproducibility, high sensitivity and high specificity, by identifying all heparin-dependent antibodies, and by miming the binding mechanism of antibodies in vivo, on heparin present at the cell surface, especially on platelets or endothelial cells.

Controls are included in the kit.

See the Hit Assay Sales Sheet


ZYMUTEST HIA kits offer a range of immuno-assays designed for testing heparin dependent antibodies, involved in the development of Heparin Induced Thrombocytopenia (HIT) or Heparin Induced Thrombocytopenia and Thrombosis (HITT). ZYMUTEST HIA, IGAM (ARK040D) measures the total antibodies, offering the highest sensitivity as all isotypes are detected. It is the preferred assay when an early detection of heparin dependent antibodies is required for assessing the development risk of HIT/HITT. ZYMUTEST HIA, IgG (ARK040A) measures only the IgG isotype, which is reported as being the most associated with the clinical complications of heparin dependent antibodies (HIT/HITT), allowing confirmation of the diagnosis of HIT/HITT or its clinical suspicion. However, some cases associated with only IgM and/or IgA isotypes can be missed. ZYMUTEST HIA, IgG, IgM and IgA (ARK040E) is designed for the full isotyping of heparin dependent antibodies, applications to characterize isotype distribution in patients with a risk or a suspicion of HIT/HITT, or for research investigations. ZYMUTEST.

Zymutest HIA IgGAM and Zymutest HIA IgG are now 510k cleared for in vitro medical diagnostic testing.




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